In this episode, I’ll discuss an article about starting norepinephrine before fluid resuscitation is complete in septic shock. Subscribe on iTunes, Android, or Stitcher Article Effects of very early start of norepinephrine in patients with septic shock: a propensity score-based analysis Lead author: Gustavo A. Ospina-Tascón Published in the journal Critical Care February 2020 Background […]

In this episode, I’ll discuss tips for implementing a PGY-1 rotation experience. Subscribe on iTunes, Android, or Stitcher 1. Make your expectations clear at the beginning of the rotation. 2. Provide a thorough orientation including review of the objectives. Plan to spend at least 30-60 minutes of day one on this. 3. When you give […]

In this episode, I’ll discuss an article about the effects of epinephrine infusion on survival in critically ill patients. Subscribe on iTunes, Android, or Stitcher Article Effect of Continuous Epinephrine Infusion on Survival in Critically Ill Patients: A Meta-Analysis of Randomized Trials Lead author: Alessandro Belletti Published in Critical Care Medicine February 2020 Background While […]

In this episode, I’ll discuss whether patients with antibiotic-impregnated bone cement should receive therapeutic drug monitoring. Subscribe on iTunes, Android, or Stitcher Shoutout to Pharmacy Kelsey for inspiring this episode. When orthopedic surgeons place bone cement in patients, they will often impregnate the cement with antibiotics such as vancomycin and tobramycin. This mixing process occurs […]

In this episode I’ll, discuss an article about using buprenorphine as an antidote in methadone overdose. Subscribe on iTunes, Android, or Stitcher Article Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial Lead author: Nasim Zamani Published in Critical Care February 2020 Background While naloxone is the standard treatment […]

In this episode, I’ll discuss cefazolin underdosing and the risk of surgical site infection. Subscribe on iTunes, Android, or Stitcher There has been a lack of solid outcome data in the literature to support recommendations for weight-based dosing of cefazolin to prevent surgical site infection in orthopedic patients. But recently researchers evaluated patients in New […]

In this episode, I’ll discuss dealing with and preventing negative interactions with other professionals. Subscribe on iTunes, Android, or Stitcher We’ve all been yelled at or had a professional interaction go sour at some point in our career. Perhaps it was when trying to deliver a recommendation to a physician, ask a question of a […]

In this episode, I’ll discuss whether D-dimer results can be improved by adjusting cutoffs for renal dysfunction. Subscribe on iTunes, Android, or Stitcher Patients with suspected thromboembolic disease who have a low or intermediate pretest probability often have a D-dimer level drawn as part of their workup before a decision to anticoagulate is made. The […]

In this episode, I’ll discuss a long-awaited randomized, controlled trial of vitamin C, thiamine, and hydrocortisone in sepsis. Subscribe on iTunes, Android, or Stitcher Article Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock Lead author: Tomoko Fujii Published in JAMA […]

In this episode, I’ll discuss the discrepancy between the labeled dose and the analgesic ceiling dose of IV ketorolac. Subscribe on iTunes, Android, or Stitcher Shout out to “Pharmacy Kelsey” for inspiring this episode! If ketorolac is 100% bioavailable, why is the oral maximum daily dose 40 mg while the IV maximum daily dose is 120 […]

In this episode, I’ll discuss an article about using piperacillin-tazobactam for the treatment of ESBL pyelonephritis. Subscribe on iTunes, Android, or Stitcher If you are listening to this recording before 10 pm EST on Tuesday, January 28th you can get a $1, 7 day trial to the Hospital Pharmacy Academy by going to pharmacyjoe.com/trial. The Hospital Pharmacy […]

In this episode, I’ll discuss whether to use actual, ideal, or adjusted body weight when dosing gentamicin in pregnant patients. Subscribe on iTunes, Android, or Stitcher Aminoglycosides such as gentamicin are very rarely used in pregnancy to treat infections. Gentamicin crosses the placenta, and is pregnancy category D. Case reports of congenital deafness following maternal […]