In this episode, I’ll discuss adjunctive inhaled antibiotics for ICU patients with pneumonia and invasive ventilation. Subscribe on iTunes, Android, or Stitcher A theoretical benefit of using adjunctive inhaled antibiotics to treat ICU patients with pneumonia and invasive ventilation is that it allows for high concentrations at the site of the infection and the potential […]

In this episode, I’ll discuss why the CAP guidelines do not recommend treating most cases of suspected aspiration pneumonia with broadening antibiotic therapy. Subscribe on iTunes, Android, or Stitcher Broadening therapy in community-acquired pneumonia to cover potential anaerobes in the case of suspected aspiration pneumonia is a common occurrence. This results in the use of […]

In this episode, I’ll review the 4 clinical teaching roles for residency preceptors. Subscribe on iTunes, Android, or Stitcher The 4 teaching roles that ASHP wants PGY-1 residency preceptors to use are: 1. Instructing 2. Modeling 3. Coaching 4. Facilitating ASHP expects that PGY-1 residency preceptors have a working knowledge of these roles. During a […]

In this episode, I’ll discuss at what dose of norepinephrine is it best to add vasopressin for patients with septic shock. Subscribe on iTunes, Android, or Stitcher While vasopressin is certainly the next vasopressor to use after norepinephrine is started in a patient with hypotension from septic shock, nobody has demonstrated the ideal level of […]

In this episode, I’ll discuss the effects of ketamine infusion rate and cumulative dosing on the incidence of delirium in medical intensive care unit patients. Subscribe on iTunes, Android, or Stitcher Way back with the 2018 Pain, Agitation, Delirium, Immobility and Sleep Guidelines, ketamine was given the following positive recommendation for the use of ketamine […]

In this episode, I’ll discuss how to become a peer reviewer for a medical journal. Subscribe on iTunes, Android, or Stitcher One common reason for a pharmacist to wish to become a peer reviewer for a journal is to satisfy ASHP standards for preceptors in the area of ongoing professionalism. Additionally, being a peer reviewer […]

In this episode, I’ll discuss antibiotic exposure and the emergence of multidrug-resistant bacteria in patients with liver cirrhosis. Subscribe on iTunes, Android, or Stitcher Patients with advanced chronic liver disease and acute-on-chronic liver failure often have indications for antibiotic use, however this increases the risk of developing an infection with a multi-drug resistant organism (MDRO). […]

In this episode, I’ll discuss a tip to predict pharmacotherapy needs in rapid response or emergent situations. Subscribe on iTunes, Android, or Stitcher At the beginning of any rapid response or emergent procedure such as rapid sequence intubation, make a note of your patient’s starting heart rate, rhythm, oxygen saturation, and blood pressure. Any significant […]

In this episode, I’ll discuss the effect of ondansetron on respiratory drive in patients with acute respiratory distress syndrome. Subscribe on iTunes, Android, or Stitcher One of the complicating issues of treating patients with acute respiratory distress syndrome is when they have excessive respiratory effort, which leads to further lung injury. Excessive sedative and paralytic […]

In this episode, I’ll discuss whether a quinolone is really superior to a macrolide for legionella pneumonia. Subscribe on iTunes, Android, or Stitcher Traditionally it is thought that a bacteriocidal antibiotic is preferable to a bacteriostatic one, especially in severe infections such as legionella pneumonia. This leads many clinicians to assume that a quinolone such […]

In this episode, I’ll discuss the performance of lidocaine vs. amiodarone for refractory ventricular fibrillation or tachycardia in in-hospital cardiac arrest. Subscribe on iTunes, Android, or Stitcher Current resuscitation guidelines recommend the use of either amiodarone or lidocaine for refractory ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT). To date, this recommendation has been primarily […]

In this episode, I’ll discuss a systematic review and meta-analysis on the ability of linezolid and clindamycin to inhibit bacterial toxin production in critically ill adults. Subscribe on iTunes, Android, or Stitcher In episode 1162, I discussed a review article where the authors concluded that linezolid inhibits bacterial toxin production just as well as clindamycin. […]