In this episode I’ll: 1. Discuss an article about allometric dosing of vancomycin. 2. Answer the drug information question “How long should steroids be given for severe alcoholic hepatitis?” 3. Share a resource for calculating the allometric dosing of vancomycin. Article Allometric versus consensus guideline dosing in achieving target vancomycin trough concentrations Lead author: Matthew […]
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Episode 192: Sodium bicarbonate alternatives due to the current shortage
In this episode, I’ll discuss the alternatives to sodium bicarbonate given the current drug shortage. Subscribe on iTunes, Android, or Stitcher This isn’t the first time we’ve had to deal with a sodium bicarbonate shortage. Back in 2012 there was also a bicarb shortage…but this time it is more complicated. The two alternatives to sodium […]
Episode 191: Effects of IV push administration on beta-lactam pharmacodynamics, duration of octreotide in variceal bleeding, and a video based resource
In this episode I’ll: 1. Discuss an article about the effects of IV push administration on beta-lactam pharmacodynamics. 2. Answer the drug information question “How long should octreotide be continued in patients with variceal bleeding?” 3. Share a video-based resource that explains complex ICU topics to patients and students. Subscribe on iTunes, Android, or Stitcher […]
Episode 190: Do patients taking warfarin for atrial fibrillation require bridging?
In this episode, I’ll discuss whether patients taking warfarin for atrial fibrillation require bridging. Subscribe on iTunes, Android, or Stitcher Background For almost 10 years, guidelines have recommended bridge therapy for patients taking warfarin for atrial fibrillation. When anticoagulation needs to be temporarily withheld, bridge therapy with a shorter-acting anticoagulant is used to reduce the […]
Episode 189: Preventing post-extubation stridor, giving ceftriaxone for variceal bleeding, and a resource for antibiotic information
In this episode I’ll: 1. Discuss an article about post-extubation stridor. 2. Answer the drug information question “Why should patients with variceal bleeding receive ceftriaxone?” 3. Share a resource for antibiotic information. Subscribe on iTunes, Android, or Stitcher The article for this episode recently appeared in a weekly literature digest for members of my Critical […]
Episode 188: The use of volatile anesthetic agents (isoflurane, desflurane, sevoflurane) for ICU sedation
In this episode, I’ll discuss the use of volatile anesthetic agents for ICU sedation. Subscribe on iTunes, Android, or Stitcher Background The concept of using volatile agents for ICU sedation is something that has been studied and marketed for over a decade internationally. With the focus on preventing the development of ICU delirium, volatile anesthetic […]
Episode 187: Combination antibiotic bag (CAB) in severe sepsis and septic shock
In this episode, I’ll discuss an abstract by a pharmacy resident about the use of a combination antibiotic bag (CAB) in severe sepsis and septic shock. Subscribe on iTunes, Android, or Stitcher At the NYSCHP annual assembly, I saw a presentation about a novel way to increase compliance with the sepsis core measure bundle of […]
Episode 186: The risk of anesthetic awareness when giving rocuronium before ketamine (rocketamine) in rapid sequence intubation
In this episode, I’ll discuss a Monte Carlo analysis I performed to assess the risk of anesthetic awareness when giving rocuronium before ketamine (rocketamine) in rapid sequence intubation. Subscribe on iTunes, Android, or Stitcher Background Recently, Dr. Josh Farkas at pulmcrit.org wrote an excellent post discussing whether in certain scenarios rocuronium should be administered before […]
Episode 185: Antibiotics in the ambulance to avoid emergency department delays, protease inhibitors for necrotizing fasciitis, and a simple way to get ACPE credits
In this episode I’ll: 1. Discuss an article about antibiotic delays for septic patients. 2. Answer the drug information question “Can protease inhibitors be used in necrotizing fasciitis?” 3. Share a resource for ACPE CE credits. Subscribe on iTunes, Android, or Stitcher Article Delays From First Medical Contact to Antibiotic Administration for Sepsis Lead author: […]
Episode 184: What is the analgesic ceiling dose of ketorolac?
In this episode, I will discuss the analgesic ceiling dose of ketorolac. Subscribe on iTunes, Android, or Stitcher Back in episode 151, I discussed a trial by Sergey Motov that demonstrated IV ketorolac has an analgesic ceiling dose of 10 mg. Recently, Ken Milne discussed this study on the Skeptics Guide to Emergency Medicine. […]
Episode 183: Piperacillin-tazobactam pharmacokinetics in critically ill patients, how quick do you need dantrolene in MH, and false positive urine drug screens
In this episode I’ll: 1. Discuss an article about piperacillin-tazobactam pharmacokinetics in critically ill patients. 2. Answer the drug information question “How quickly must dantrolene be accessible to treat a case of malignant hyperthermia (MH)?” 3. Share a resource about false positive urine drug screens. Subscribe on iTunes, Android, or Stitcher The article for this […]
Episode 182: Alternative anticoagulation strategies for continuous renal replacement therapy during the calcium shortage
In this episode, I’ll discuss alternative anticoagulation strategies for continuous renal replacement therapy during the calcium shortage. Subscribe on iTunes, Android, or Stitcher According to the ASHP current drug shortages list, both calcium chloride and calcium gluconate are in short supply due to manufacturing delays. The “local anticoagulation” method of using citrate during continuous renal […]
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