In this episode I’ll: 1. Review the updated CHEST guidelines on Antithrombotic Therapy for VTE Disease. 2. Answer the drug information question: “Can I continue metronidazole for prevention of recurrent clostridium difficile infection (CDI) in patients requiring antimicrobial therapy?” 3. Share a resource I wear around my wrist. Subscribe on iTunes, Android, or Stitcher Shout […]
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Episode 56: Why the Cockcroft-Gault formula can’t be used to calculate creatinine clearance
In this episode I’ll discuss a long time pet peeve of mine – the Cockcroft Gault formula can be used to predict – not calculate – creatinine clearance. Subscribe on iTunes, Android, or Stitcher 40 years after it’s publication, the Cockcroft Gault formula remains the most appropriate method of estimating kidney function for the purpose […]
55: Sux vs roc in brain injury, stopping antibiotics in fecal microbiota transplant & more
In this episode I’ll: 1. Discuss an article that found an increase in mortality when succinylcholine was used for rapid sequence intubation in patients with traumatic brain injury. 2. Answer the drug information question “Do antibiotics need to be stopped prior to fecal microbiota transplantation (FMT) to treat clostridium difficile infection?” 3. Share a resource I use during […]
54: Daptomycin use in adult critical care patients
In this episode I’ll discuss the use of daptomycin in the context of adult critically ill patients. Subscribe on iTunes, Android, or Stitcher Mechanism of action Daptomycin demonstrates concentration-dependent bactericidal activity against essentially all gram positive organisms. It has a unique mechanism of action. Daptomycin binds to bacterial cell membranes and causes a rapid depolarization of membrane […]
53: Pain assessment in the setting of ICU delirium
In this episode I’ll: 1. Discuss an article about evaluating the presence of pain in patients with ICU delirium 2. Answer the drug information question: “Does quetiapine reduce the duration of ICU delirium?” 3. Share a resource I use to find information about the prevention and treatment of ICU delrium Subscribe on iTunes, Android, or […]
52: Treatment of inpatient hypoglycemia
In this episode I’ll review the inpatient treatment of hypoglycemia. Subscribe on iTunes, Android, or Stitcher Hypoglycemia is a medical emergency To help myself remember and apply medical concepts, I break them down into the most simple terms I can. While most rapid response calls are for problems related to oxygen delivery, hypoglycemia is a problem […]
51: DDAVP for intracranial hemorrhage, re-exposure to heparin after HIT, and bacterial classification resources
In this episode I’ll: 1. Discuss an article recommending DDAVP for intracranial hemorrhage from anti-platelet agents 2. Answer the drug information question: “What should I use to treat a DVT in a patient on CRRT with a recent history of HIT?” 3. Share a resource I use to get an early clue on the identification […]
50: Overdose scenarios in which supportive care is not enough – acetaminophen, methanol, or ethylene glycol poisoning
In this episode I’ll focus on 2 examples of medication overdose that require more than supportive care to treat effectively: 1. Acetaminophen poisoning 2. Methanol & ethylene glycol poisoning Subscribe on iTunes, Android, or Stitcher A special shout out to my kids for the artwork & audio bumper for this episode! Many poisons, few antidotes […]
49: Fixed dosing of 4 factor prothrombin complex concentrate, full dose subcutaneous heparin, and pneumotox
In this episode I’ll: 1. Review an article about fixed dosing of 4-factor prothrombin complex concentrate for emergent warfarin reversal 2. Answer the drug information question: What is the dose of subcutaneous heparin to provide full therapeutic anticoagulation? 3. Share a resource for information about drug-induced & iatrogenic respiratory disease Subscribe on iTunes, Android, or […]
48: Pharmacologic Support In The Treatment Of Shock
In this episode I’ll review the medications used to support the treatment of shock from 12 different etiologies. Subscribe on iTunes, Android, or Stitcher During the treatment of shock, the patient’s life hangs in the balance while the care team quickly delivers interventions to identify and treat the underlying cause. Many of these interventions require […]
47: Augmented renal clearance, endocarditis treatment, and tPA risk vs benefit
In this episode I’ll: 1. Review an article about augmented renal clearance of antibiotics in critically ill patients 2. Answer the drug information question “For a patient with rash to penicillin that is 5 months s/p TAVR and has 4/4 bottles positive for gram positive cocci resembling staph, what antibiotic regimen should be used?” 3. […]
46: Pharmacologic treatments for anaphylaxis
In this episode I’ll review the pharmacologic treatments for anaphylaxis. Subscribe on iTunes, Android, or Stitcher Definition Anaphylaxis is a potentially fatal allergic reaction with a rapid onset. Immunoglobulin E (IgE)-mediated allergic reactions to food, insect stings and medications are the most common triggers for anaphylaxis. As a result of the IgE reaction, mast cells […]
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