In this episode I’ll: 1. Discuss an article on the pharmacodynamics of a fluid challenge. 2. Answer the drug information question “Why is epinephrine added to lidocaine for injection?” 3. Share a resource for staying up to date with FDA safety information. Subscribe on iTunes, Android, or Stitcher Article Pharmacodynamic Analysis of a Fluid Challenge […]
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82: Cyanide poisoning
In this episode I’ll discuss cyanide toxicity. Subscribe on iTunes, Android, or Stitcher Cyanide is a rapidly lethal toxin. It causes death within minutes to hours of exposure. Cyanide inhibits oxidative phosphorylation in the mitochondria, shutting down aerobic metabolism. Oxygen supply remains adequate but cells are unable to utilize the oxygen. Cyanide is present in […]
81: Tigecycline for clostridium difficile, mycophenylate induced aveolar hemorrhage, and a warfarin dosing resource
In this episode, I’ll: 1. Discuss an article about using tigecycline for clostridium difficile infection. 2. Answer the drug information question “Has mycophenolate ever been associated with aveolar hemorrhage?” 3. Share a resource that can be used to determine a patient’s warfarin dose. Subscribe on iTunes, Android, or Stitcher When tigecycyline first arrived on the […]
80: Phenytoin dosage, adjustment, and monitoring
In this episode I’ll discuss the drug phenytoin. Subscribe on iTunes, Android, or Stitcher Indications Common indications for the use of phenytoin are: Control of generalized tonic-clonic and complex partial (psychomotor, temporal lobe) seizures Prevention and treatment of seizures occurring during or following neurosurgery Prevention of early (within 1 week) post-traumatic seizures following traumatic brain […]
79: Methylprednisolone shortage alternatives
If you haven’t been hit by the methylprednisolone shortage yet, get ready…it looks like it may be coming to a pharmacy near you! Subscribe on iTunes, Android, or Stitcher According to the ASHP drug shortage bulletin, 40 and 125 mg vials of methylprednisolone are in short supply. Pfizer appears to be experiencing a manufacturing delay, […]
Episode 78: Correlating mechanism of action to pathophysiology of disease
In this episode I’ll discuss my secret to learning, recalling, and applying pharmacotherapy knowledge to patient care: correlating mechanism of action to the pathophysiology of disease. Subscribe on iTunes, Android, or Stitcher Earlier in my career, I noticed that most physicians and some other more experienced clinicians seem to have this natural ability to apply […]
77: Acute kidney injury with vanco & pip-taz, hypotonic dextrose for hypernatremia, G6PD resources
In this episode I’ll: 1. Discuss an article that looks at the incidence of acute kidney injury in ICU patients receiving vancomycin and piperacillin-tazobactam 2. Answer the drug information question “Should 2.5% dextrose ever be infused?” 3. Share a resource about G6PD deficiency Subscribe on iTunes, Android, or Stitcher Article Comparative Incidence of Acute Kidney […]
76: How to use dexmedetomidine for ICU sedation and ventilator weaning
In this episode I’ll discuss how to use dexmedetomidine for sedation in the ICU. Subscribe on iTunes, Android, or Stitcher If you are wondering about the use of dexemedetomine in agitated delirium or alcohol withdrawal, check out episodes 67 & 70. Mechanism of action Dexmedetomidine is a selective a2-adrenoceptor agonist. I like to think of […]
75: When will the FDA approve ciraparantag / PER977?
In this episode I’ll discuss the drug ciraparantag. Subscribe on iTunes, Android, or Stitcher Shout out to Pharmacy Lawrence on Twitter for requesting this topic! If you are not on Twitter you should consider it. I believe it is the best social media platform to use for education and collaboration with other healthcare providers. For more information […]
74: Monitoring continuous infusions of neuromuscular blocking agents (NMBAs)
In this episode I’ll discuss monitoring continuous infusions of neuromuscular blocking agents. Subscribe on iTunes, Android, or Stitcher The non-depolarizing neuromuscular blocking agents (NMBAs) cisatracurium, rocuronium, and vecuronium are occasionally given as a continuous infusion in critically ill patients. These medications paralyze all skeletal muscle, including the diaphragm muscle. Adverse effects NMBAs, especially the steroid-based rocuronium […]
73: Calcium correction in the ICU, IVIG dosing weight, and open access medical journals
In this episode I’ll: 1. Discuss an article about calcium correction in the ICU 2. Answer the drug information question “What weight should be used to calculate an initial dose of IV immune globulin (IVIG)?” 3. Share a resource about open access medical journals. Subscribe on iTunes, Android, or Stitcher Article Ionized Calcium in the […]
72: How to taper off a fentanyl infusion
In this episode I’ll discuss how to taper patients off a fentanyl infusion: Subscribe on iTunes, Android, or Stitcher If a patient has been on a continuous fentanyl infusion for 7 or more days, they are likely to have physical signs of opioid withdrawal if the infusion is suddenly stopped. This is a fairly regular […]
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