In this episode, I’ll discuss how to answer a question like an experienced pharmacist, even if you’re brand new. Subscribe on iTunes, Android, or Stitcher The ED physician calls you on the phone and asks “What is the half-life of methadone?” How should you answer this question? This question is an example of an obscure […]
Episode 669: Is this the most important article on vancomycin ever published?
In this episode, I’ll discuss a recent article about vancomycin monitoring. Subscribe on iTunes, Android, or Stitcher Shout out to “Pharmacy David,” “Pharmacy Lisa,” and “Pharmacy Kathryn” at the Department of Pharmacy Practice & Science, University of Arizona for inspiring this episode! I can’t remember ever being as excited about a journal article as I […]
Episode 668: Is oral valganciclovir really as good as IV ganciclovir for the treatment of CMV infection?
In this episode, I’ll discuss whether oral valganciclovir is really as good as IV ganciclovir for the treatment of CMV infection. Subscribe on iTunes, Android, or Stitcher Shout out to “Pulmonary Ashley” for inspiring this episode! When considering therapy to treat a CMV infection, multiple references suggest that oral therapy with valganciclovir is noninferior or […]
Episode 667: If Nebulized Formoterol is Compatible with Most Other Nebulized Medications, Why Are They Not Recommended To Be Mixed?
In this episode, I’ll discuss the compatibility of nebulized formoterol with other common nebulized medications. Subscribe on iTunes, Android, or Stitcher In 2008, an article was published that found admixtures of formoterol with budesonide, ipratropium, cromolyn, or acetylcysteine to be physically and chemically compatible. The study was thorough and used appropriate methods to determine compatibility. […]
Episode 666: What happens if you accidentally get rocuronium in your eye?
In this episode, I’ll discuss what happens if you accidentally get rocuronium in your eye. Subscribe on iTunes, Android, or Stitcher While the Material Safety Data Sheet for rocuronium states “…inadvertent eye contact with this product may produce irritation with redness and discomfort,” there were no reports of accidental ocular exposure to rocuronium until recently. […]
Episode 665: When is using IV bicarb in the ICU actually helpful?
In this episode, I’ll discuss when using IV bicarb in the ICU is actually helpful. Subscribe on iTunes, Android, or Stitcher If used to attempt to normalize pH without correcting the underlying problem, sodium bicarbonate use is essentially pointless as its effects will be short-lived. In addition, indiscriminate bicarb use should be avoided due to potential adverse […]
Episode 664: Does the shorter duration of midazolam vs lorazepam persist when combined with haloperidol?
In this episode, I’ll discuss the effects of ED length of stay when using either midazolam+haloperidol or lorazepam+haloperidol for acute agitation. Subscribe on iTunes, Android, or Stitcher Midazolam has a faster onset and shorter time to awakening than lorazepam. ED treatment of acute agitation often includes haloperidol given in combination with a benzodiazepine, and it is […]
Episode 663: What are the effects of morbid obesity on filgrastim pharmacokinetics?
In this episode, I’ll discuss the effects of morbid obesity on filgrastim pharmacokinetics. Subscribe on iTunes, Android, or Stitcher The prescribing information for filgrastim recommends dosing based on actual body weight, but this results in large doses for morbidly obese patients. The original data for filgrastim only used patients who were at an ideal body weight, […]
Episode 662: One hospital’s evolution of the U-500 insulin use process
In this episode, I’ll discuss one hospital’s evolution of the U-500 insulin use process. Subscribe on iTunes, Android, or Stitcher Medication errors with U-500 insulin can be serious, and ensuring the safe use of this medication in a hospital setting has presented hospital pharmacies with considerable challenges. Recently, more tools have become available to facilitate the […]
Episode 661: Fentanyl Patch Safety in Hospitals
In this episode, I’ll discuss new orders for fentanyl patches in the hospital setting. Subscribe on iTunes, Android, or Stitcher Transdermal fentanyl patches are contraindicated in the treatment of acute pain or in patients who are not opioid tolerant. This contraindication is in response to many reports of severe and fatal patient harm from the use […]
Episode 660: Does colchicine work in patients admitted to hospital with COVID-19?
In this episode, I’ll discuss colchicine in patients admitted to hospital with COVID-19. Subscribe on iTunes, Android, or Stitcher When steroids like dexamethasone were found effective for COVID-19, it was logical to wonder whether colchicine, with its anti-inflammatory properties, would also help improve outcomes of patients with COVID-19. The RECOVERY Trial, which is a randomized, controlled, […]
Episode 659: If 6 mg dexamethasone is good then why not 12?
In this episode, I’ll discuss the dose of dexamethasone for patients with COVID-19. Subscribe on iTunes, Android, or Stitcher Current recommendations are for a daily dose of 6 mg dexamethasone for up to 10 days in patients with severe and critical COVID-19. This dose was not determined by a dose-finding study, rather it was the single-dose […]
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