In this episode, I’ll discuss a case of antidepressant discontinuation syndrome in the ICU. Subscribe on iTunes, Android, or Stitcher Antidepressant discontinuation syndrome has a significant potential to occur in ICU patients. This could be from unrecognized withdrawal from the antidepressant when home medications are stopped during the initial treatment of critical illness or from […]
Episode 869: Three Recent Studies About Haloperidol and ICU Delirium
In this episode, I’ll discuss haloperidol for ICU delirium. Subscribe on iTunes, Android, or Stitcher Despite efforts to reduce the incidence of ICU delirium with light sedation techniques, many patients still end up with delirium during their stay in the ICU. Some of these patients develop agitated delirium that requires treatment so the patient does […]
Episode 868: One Weird Trick Let These ED Pharmacists Double Antibiotic-Free Days
In this episode, I’ll discuss a pharmacist-driven deprescribing protocol for negative urine and sexually transmitted infection cultures in the emergency department. Subscribe on iTunes, Android, or Stitcher When pharmacists begin to provide in-person services to the Emergency Department, one of the first areas to achieve an impact that everyone is satisfied with is the ED […]
Episode 867: How common is awareness with paralysis in the ED after RSI?
In this episode, I’ll discuss the frequency of awareness with paralysis in the ED. Subscribe on iTunes, Android, or Stitcher Rapid sequence intubation is a common procedure in the ED. After this procedure where a paralytic such as succinylcholine or rocuronium has been used along with a short-acting sedative such as propofol, ketamine, or etomidate, […]
Episode 866: Can 3 Days of Inhaled Amikacin Prevent VAP?
In this episode, I’ll discuss inhaled amikacin to prevent VAP. Subscribe on iTunes, Android, or Stitcher The prevention of ventilator associated pneumonia has been a focus of research for many decades. The peak incidence of VAP appears to occur after about 7 days of ventilator use and this has led researchers to focus on whether […]
Episode 865: Predicting Success of Dexmedetomidine as a Sedative
In this episode, I’ll discuss predicting the success of dexmedetomidine as a sedative. Subscribe on iTunes, Android, or Stitcher Anecdotally, dexmedetomidine has always seemed like a hit-or-miss sedative, working wonderfully in many patients and barely or not at all in others. Researchers recently published in Pharmacotherapy a single-center, retrospective, cohort study of 158 critically ill […]
Episode 864: Why Did ISMP Remove the Do Not Crush List from Their Website?
In this episode, I’ll discuss what happened to the “ISMP’s Do Not Crush List.” Subscribe on iTunes, Android, or Stitcher If you navigate to the page on the website for the Institute for Safe Medication Practices that once hosted the document titled “Oral Dosage Forms That Should Not Be Crushed” you will instead find a notice […]
Episode 863: Does This Randomized Trial Settle the Increased AKI from Piperacillin-Tazobactam Question?
In this episode, I’ll discuss an article about cefepime vs piperacillin-tazobactam in adults hospitalized with acute infection. Subscribe on iTunes, Android, or Stitcher Because piperacillin-tazobactam and cefepime have similar cost and coverage vs gram-negative bacteria, the choice of which agent to use in hospitalized patients with acute infection comes down to differences in adverse effect profiles. […]
Episode 862: Why hypokalemia can result from digoxin immune fab fragment administration
In this episode, I’ll discuss why hypokalemia can result from digoxin immune fab fragment administration. Subscribe on iTunes, Android, or Stitcher In the setting of digoxin toxicity, the sodium-potassium ATPase pump is impaired and potassium shifts from the intracellular to extracellular space. With the administration of antidote therapy with digoxin immune fab fragments, the function of […]
Episode 861: When Diluents Attack! A Case Report of Seizure From Esmolol In Sterile Water
In this episode, I’ll discuss a case report of seizures precipitated by esmolol in sterile water formulation. Subscribe on iTunes, Android, or Stitcher A case report recently published in American Journal of Health-System Pharmacy highlights the potential for a drug diluent to have significant adverse clinical consequences. The case is that of a 34-year-old male […]
Episode 860: 4 Factors That Can Predict Agitation in Lightly Sedated Ventilated Patients
In this episode, I’ll discuss the 4 factors that predict agitation in lightly sedated ventilated patients. Subscribe on iTunes, Android, or Stitcher Light sedation is encouraged in ventilated patients due to less delirium. However agitation is one of the risks of a light sedation strategy. If the agitation is not treated in time, a patient […]
Episode 859: Three Important Parts of the SCCM Rapid Sequence Intubation Guidelines
In this episode, I’ll discuss the SCCM Rapid Sequence Intubation Guidelines. Subscribe on iTunes, Android, or Stitcher The SCCM recently published Clinical Practice Guidelines for Rapid Sequence Intubation in the Critically Ill Adult Patient. While any pharmacist that works in a critical care setting should take the time to read these new guidelines, there are […]
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