In this episode, I’ll discuss an article about which vasopressor is best in early traumatic brain injury patients. Subscribe on iTunes, Android, or Stitcher Patients who have severe traumatic brain injury and develop hypotension that requires vasopressor therapy are already at risk for mortality and poor long term outcomes. But could the choice of vasopressor […]
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Episode 693: Fondaparinux in critically ill patients with severe renal dysfunction
In this episode, I’ll discuss an article about using fondaparinux in critically ill patients with severe renal dysfunction. Subscribe on iTunes, Android, or Stitcher Evaluating options for venous thromboembolism (VTE) prophylaxis in critically ill patients is challenging and many issues can limit options including renal failure, bleeding risk, and thrombocytopenia. Fondaparinux use is often […]
Episode 692: Is the story for vitamin C in critically ill patients over?
In this episode, I’ll discuss the use of vitamin C in critically ill patients. Subscribe on iTunes, Android, or Stitcher Even before the combination of vitamin C with thiamine and hydrocortisone was published, researchers have been exploring the potential benefit of vitamin C use in critically ill patients. The journal Critical Care Medicine has recently […]
Episode 691: How does obesity affect SC and IM medication administration?
In this episode, I’ll discuss how obesity affects SC and IM medication administration. Subscribe on iTunes, Android, or Stitcher The thickness of the subcutaneous layer increases with obesity and this has potential implications for both subcutaneous and intramuscular medication administration. The AJHP recently published a review article on the implications of obesity for drug administration […]
Episode 690: What is the incidence of torsades from low-dose ondansetron in peri-operative patients?
In this episode, I’ll discuss the incidence of torsades from low-dose ondansetron in peri-operative patients. Subscribe on iTunes, Android, or Stitcher Ondansetron prescribing information has a warning that Electrocardiogram (ECG) changes including QT interval prolongation have been seen in patients receiving ondansetron. Some references list this as a concern, but many clinicians believe that a […]
Episode 689: What is the best vasopressor to use in post-resuscitation shock?
In this episode, I’ll discuss what vasopressor to use in post-resuscitation shock. Subscribe on iTunes, Android, or Stitcher The ideal choice of vasopressor for post resuscitative shock is unknown, and researchers from the Paris Cardiovascular Research Center conducted an observational multicenter study to determine whether epinephrine or norepinephrine was the superior vasopressor to use in […]
Episode 688: The 4 categories of interventions to treat medication overdose and why antidote is not #1
In this episode, I’ll discuss the 4 categories of interventions to treat medication overdose and why antidote is not #1. Subscribe on iTunes, Android, or Stitcher I consider the 4 categories of interventions to treat medication overdose to be: #1 Supportive care #2 Antidote therapy #3 Decontamination #4 Enhance elimination As pharmacists, it is easy […]
Episode 687: How to decide when to give rabies immune globulin?
In this episode, I’ll discuss when rabies immune globulin is indicated. Subscribe on iTunes, Android, or Stitcher Rabies immune globulin (RIG) administration is part of successful rabies post-exposure prophylaxis. The rabies vaccine produces active immunity beginning about 7 to 10 days after the vaccine series is started. However, when RIG is given, passive immunity is […]
Episode 686: What are the risks for serious and general opioid-related adverse drug events?
In this episode, I’ll discuss an article about serious and general opioid-related adverse drug events. Subscribe on iTunes, Android, or Stitcher Opioid-related adverse effects in hospital inpatients can be a significant cause of morbidity and resource expenditure in the form of rapid response calls, transfers to higher levels of care, and extended length of stay. […]
Episode 685: What is the feasibility of low-concentration peripheral norepinephrine infusion?
In this episode, I’ll discuss an article about low-concentration peripheral norepinephrine infusion. Subscribe on iTunes, Android, or Stitcher Peripheral vasopressor administration is generally considered desirable by clinicians in 2 scenarios: 1. A patient’s blood pressure is severely low and waiting for a central line to be placed could cause organ damage due to low perfusion. […]
Episode 684: The hyperkalemia article we’ve all been waiting for
In this episode, I’ll discuss an article about patiromer for hyperkalemia in hospitalized patients. Subscribe on iTunes, Android, or Stitcher Everybody dislikes using sodium polystyrene sulfate due to its potential for rare but serious side effects like intestinal necrosis. But newer agents for removing excess potassium from the body have limited data in patients with […]
Episode 683: Is phentolamine the only thing you can use for vasopressor extravasation?
In this episode, I’ll discuss if phentolamine the only thing you can use for vasopressor extravasation. Subscribe on iTunes, Android, or Stitcher Extravasation is a complication of IV therapy that refers to the infiltration of tissues with a medication that is an irritant or vesicant. Infiltration can be done purposefully with therapeutic intent, such as […]
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